Muhammad Irfan Tahir Khan, Muhammad Ammar Rashid, Muhammad Atif Imran, Aamir Hussain, Ahmad Noeman, Muhammad Ayub.
Prevalence of asymptomatic coronary artery disease on 99m TC-SESTAMIBI spect in chronic kidney disease patients.
J Cardiovascular Dis Jan ;13(1):19-22.

OBJECTIVE:This study was conducted to evaluate the prevalence of asymptomatic coronary artery disease on 99mTC-Sestamibi SPECT in chronic kidney disease patients. MATERIAL AND METHODS:This descriptive, cross- sectional study was conducted at the Nuclear Medicine Department of Punjab Institute of Cardiology, Lahore from: 07-03-2013 to 06-09-2013 (Six Months). A total of 100 asymptomatic patients with CKD age ranging from 30-70 years of both genders with GFR less than 60ml/min/1.73m2 for 3 months were included. Patients with baseline electrocardiogram with ST-T wave changes or Q wave (changes suggestive of ongoing ischemia or an old infarct), past history of ischemic heart disease, myocardial infarction, congestive cardiac failure, post angioplasty, coronary artery bypass grafting, renal transplant and peripheral vascular disease / cerebro-vascular accident (stroke/ TIA) were excluded. RESULTS: In our study, 9 % (n=9) were between 31-40 years, 21 % (n=21) between 41-50 years, 48% (n=48) between 51-60 years and 22% (n=22) had >60 years of age, mean+sd of age was calculated as 53.25+9.09 years. Regarding gender distribution of the patients 55% (n=55) male and 45% (n=45) were female. Frequency of asymptomatic coronary artery disease on 99mtc-sestamibi SPECT in chronic kidney disease patients was 49% (n=49) while 51% (n=51) had no findings of the morbidity. CONCLUSION: In this study we recorded a significantly higher frequency of asymptomatic CAD on 99mTC-Sestamibi SPECT in chronic kidney disease patients in agreement with other international studies, but the data in our country is primary, however, more trials must be done to authenticate the findings of the study. KEYWORDS:Chronic kidney disease, asymptomatic coronary artery disease,99mTC-Sestamibi SPECT

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