Heydarpour Fereidoun, Rostami Ahmad, Sobhan Ahmad, Heydarpour Pouria.
Effect of feeding with different salt concentrations in prenatal period on the vascular response to epinephrine and acetylcholine.
Pak J Physiol Jan ;7(1):08-12.

Background: Determine the effect of prenatal exposure to different salt concentrations on the third month’s blood pressure and vascular response to epinephrine and acetylcholine. Methods: Eight groups of rat, six in each group, one male and five female were exposed to different salt concentrations, Isfahan tap water and distilled water during pre-pregnancy, pregnancy and lactation period. After blood pressure measurement in infants, in one sub-group 1% body weight of blood was substituted by the same volume of NaCl 0.9% containing 1 μg/ml epinephrine and in the other group by 0.1 μg/ml acetylcholine. Results: Salt concentrations higher than 1% increased third month’s blood pressure and vascular response to epinephrine and decreased vascular response to acetylcholine while lower salt concentrations had no significant influence. Conclusion: Level of dietary salt during intrauterine development can permanently alter the mechanisms that regulate cardiovascular function, blood pressure and vascular response to epinephrine and acetylcholine.

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