Azra Syed, Abdul Baseer, Syed Salahuddin Ahmed.
Pregnancy Induced Hypertension Hyperlipidemia, A cause of Endothelial Damage.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;5:200-4.

Endothelial cell injury and altered endothelial cell function appears to play a pivotal role in the genesis ii all aspects of the multisystem damage seen in preeclampsia. There is increasing evidence that marked perturbations in lipid and lipoprotein metabolism may also be of fundamental importance in the pathogenesis of this disorder. This study was conducted to detect and compare the plasma lipids among the normal pregnant and pregnancy induced hypertensive women. One hundred and ten pregnant women seen at the Department of Obstetrics and Gynecology, Jinnah Post Graduate Medical Center, Karachi, Pa kistan for their prenatal care were recruited. The study group was classified (A) control group (n=40), (B) Test group (n-70). This group was further subclassified into mild (n 40) and severe (n=30). in accordance to the definition presented by the American College of Obstetrics and Gynecologists. Serum total cholesterol, triglycerides and HDL cholesterol levels were estimated by the enzymatic colorimetric method. The LDL-cholesterol was cal culated according to Freidwald formula where as VLDL- cholesterol was calculated according to the formula proposed by Wilson cited by Delong et al. The increase in the mean levels of serum total cholesterol were highly significant (P<0.001) among the mild (300±0.6mg/dl) and severe (302 ±0.7mg/dl) hypertensive woman as compared to normal pregnant women (287±1.5mg/dl). The increase in the mean triacylglycerol levels was highly significant (P<0.001) among the mild (317±1.7mg/dl) and severe (314±2.5mg/dl) pregnancy induced hypertensive women as compared to normal group (238±3.7mg/dl) pregnant women. The decrease in high-density lipoprotein cholesterol was highly significant (P<0.001) in the mild (61.8±0.3mg/dl) and severe (62±0.4mg/dl) cases as compared to the normal (75.7±0.7mg/dl) pregnant levels. The low-density lipoprotein cholesterol levels were highly significant (P<0.001) in both the mild (17.5±0.7mg/ dl) and severe (179.0±0.7mg/dl) pregnancy induced hypertensive cases as compared to normal (163.7±1.42mg/dl) pregnant levels. The very low density lipoprotein cholesterol levels was also significantly high (P<0.001) among the mild (63.3±0.3mg/dl) and severe (62.8±0.5mg/dl) cases of pregnancy induced hypertensive woman as compared to normal (47.8±0.6mg/dl) pregnancy. Endothelial dysfunction of pregnancy induced hypertension is causally related to and exacerbated by alteration in the metabolism of fatty acids and triglycerides.

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