Atifa Afsheen Sharique.
Insight into Female Endocrine Infertility and its Relationship to Body Mass Index.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;21(4):214-20.

Objective: Endocrine subfertility among females is increasing worldwide due to the epidemic of obesity. The objective of this study was to determine the clinical and hormonal presentation of subfertile women of endocrine aetiology and its relationship to Body Mass Index (BMI) and to classify the causes of anovulation according to the World Health Organization (WHO). Methods: This observational, cross-sectional study was done in infertility clinic at Jinnah Medical College Hospital, from January 2015 to December 2015. Seventy-three subfertile females aged from 15 to 45 years with endocrine cause were included. After detailed history and clinical examination, ultrasound pelvis for follicular tracking and hormone profile on day 2-3 of menstruation cycle was done. Statistical analysis was done using SPSS version 20. Mean values of age and duration of subfertility with their standard deviations were determined. Results: Total 73 patients with endocrine subfertility were indentified out of which 48 (66.7%) had primary infertility and 24 (33.3%) had secondary subfertility, while the mean duration of infertility was 3.3 years (5.2 ± 4.2). Normal cycle was found in only 14 (19.2%) and 38 (52.1%) had oligomenorrhea. Significant number of patients i.e. 18 (24.7%) were known hypertensive, 22 (15.1%) had thyroid disorders, 3 (4.1%) hyperprolactinemia and Tuberculosis, 1 (1.4%). Patients with pelvic surgery and 1 (1.4%) had abdominal surgery. A normal BMI was found in 21 (31.5%), while 24 (32.9%) patients were overweight and 21 (28.8%) were obese. Conclusion: Endocrine infertility is strongly associated with (BMI). Menstrual irregularities, clinically androgen excess and galactorrhea are more frequent in obese and overweight women when compared with desirable weight. Keywords: Anovulation, infertility, female, ovulation, body mass index.

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