Uzma Yasmeen, Syed Mubarak Ali, Ali Baqar Naqvi, Muhammad Liaquat Raza.
Evaluation of Diagnostic Accuracy of Ultrasound to Detect Hepatocellular Carcinoma in Chronic Liver Disease (CLD) Patients.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;21(4):206-13.

Objective: To determine diagnostic accuracy of ultrasound to detect hepatocellular carcinoma (HCC) in chronic liver disease (CLD) patients by taking histopathology as the gold standard. Methods: Descriptive study was done in which a total of 246 patients, of either sex (age range: 20-70 years) with diagnosis of CLD for 6 months or more, were enrolled at the department of radiology, Abbasi Shaheed Hospital, Karachi from January to June 2015. Abdominal ultrasound was performed to detect any mass lesion in liver, following which all patients underwent liver biopsy under ultrasound guidance. The ultrasound diagnosis was then compared with the histopathology result to assess sensitivity, specificity and accuracy of ultrasound examinations. Informed consent was taken from all the patients. Results: Mean age of patients was 46.98 ± 6.20 years. Mean duration of chronic liver disease was 11.58 ± 3.22 months. Among 246 patients, in 102 (41.5%) patients single lesions were seen, while in 67 (27.2%) patients multiple lesion were seen. Mean size of mass was found to be 4.05 ± 1.37cm. The diagnostic accuracy of ultrasound for the diagnosis of HCC was 81.71%. Sensitivity and specificity of ultrasound for the diagnosis of HCC was 86.21% and 75.25% respectively. However, in this study positive and negative predictive values for ultrasound were 83.33% and 79.19% respectively. Statistical analysis was performed using SPSS version 10.0. Conclusion: These results are in acceptable range suggesting that ultrasound can be used for the screening and detection of HCC in patients of chronic liver disease. Keywords: Ultrasound, histopathology, hepatocellular carcinoma, chronic liver disease.

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