Ayesha Janjua, Akbar Waheed, Salman Bakhtiar.
Protective effect of pioglitazone on gentamicin induced nephrotoxicity in rabbits.
Pak Armed Forces Med J Jan ;66(1):104-8.

Objective: To evaluate potential role of pioglitazone in protecting kidneys from nephrotoxic insult produced by Gentamicin. Study design: Comparative study on animal model. Place and Duration of Study: Department of Pharmacology Army Medical College, duration of study was six months. Material and Methods: Twenty four rabbits were randomly divided into four groups (n=6). Group (Gp)-1 received 1 milliliter (ml) isotonic saline intraperitoneally (IP) daily for 13 days. Gp-2 received gentamicin 40 miligram/kilogram/day (mg/kg/day) IP daily for 13 days. Gp-3 received pioglitazone salt 10 mg/kg/day dissolved in drinking water via feeding tube for 13 days. Gp-4 received pioglitazone salt 10 mg/kg/day via feeding tube plus gentamicin 40 mg/kg/day IP for 13 days. Blood was collected on days 0 and 14 for estimation of serum urea and creatinine. All animals were sacrificed and kidneys were removed for renal histological examination. Results: Pioglitazone did not show any nephroprotective effect against gentamicin induced nephrotoxicity. Conclusion: Pioglitazone fails to exhibit nephroprotective potential when administered along with nephrotoxic dose of gentamicin.

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