Raza Muhammad, Altaf Hussain, Asmat Ullah, Khurshid Anwar, Johar Iqbal, Muneeb Khan.
Effects of Perioperative Steroids in Tonsillectomy Using Sharp Dissection Technique in Adults on First Postoperative Day.
Ann Pak Inst Med Sci Jan ;8(3):165-7.

Objective; To determine the effects of periperative dexamethasone sodium phosphate administration on post tonsillectomy morbidity for sharp dissection technique. Study Design: Randomized control study Place and Duration of the Study: The Study was conducted at the ENT Department, Hayatabad Medical Complex (HMC) and Pakistan Institute of Medical Sciences, Islamabad from March 2009 to March 2010. Materials and Methods: A total 108 patients included in the study were randomly assigned to receive either dexamethasone sodium phosphate (1 mg/kg) or placebo. Post tonsillectomy pain, oral intake and postoperative vomiting were measured on post operative day (POD) 1 . Results: A total of 54 patients received preoperative steroids and 54 patients received placebo undergoing tonsillectomy by sharp dissection technique. On POD 1 pain scores (p=0.016) were significantly lower in subjects receiving steroids than in those receiving placebo. Postoperative vomiting was reduced from 63 % (placebo group) to 25.9 % (steroid group) (p=0.02).Oral intake improved from 22.2% of normal diet (placebo group) to 31.5% (steroid group) (p=0004).when two groups were compared postoperative pain scores were significantly lower in the steroid group than in the other group. Conclusion: Perioperative dexamethasone reduces post tonsillectomy morbidity in the adult patients in the early postoperative period after cold dissection tonsillectomy.

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