Mohammad Sajjad, Hamida Qureshi, Hamidullah Shah, Zard Ali Khan.
Role Of Pleural Biopsy In Diagnosis Of Exudative Pleural Effusion.
Isra Med J Jan ;8(1):43-5.

OBJECTIVES: To find out the role of pleural biopsy in diagnosis of exudative pleural effusion. STUDY DESIGN: An Observational study. st PLACE AND DURATION: Pathology Department Bannu Medical College Bannu KPK. Pakistan. The duration was two years from 1 st January, 2012 to 31 December, 2013. METHODOLOGY: In this study 74 cases of exudative pleural effusion not otherwise specific (NOS) were included, all were subjected to blind pleural biopsy. Pleural biopsy was carried out under aseptic technique. The biopsy was fixed in formalin, processed in grades of alcohol, xylene, paraffin wax, block prepared, freezed and 5 micron thick sections taken, slide prepared and mounted in DPX, labeled and read out by histopathologist, diagnosis recorded. The data was collected on designed proforma and results analyzed using SPSS 16. RESULTS: In this study of 74 pleural biopsy the age range was 30-65 years. Male were 47 and female were 27, male to female ratio was 1.74:1. The most common age group involved was 45 to 55 years followed by 35-45 years. Out of 74 pleural biopsies the histopathology was conclusive in 67 (90.54%) cases and in 07 (9.45%) cases four cases were of nonspecific inflammation and in three cases the biopsy material was insufficient. Chronic granulomatous inflammation (tuberculosis) 45 (60.81%) cases were the commonest lesions followed by malignancy both primary and metastatic 22 (29.72%) cases, chronic nonspecific inflammation 4(5.40%) cases and in 3 (4.05%) cases the biopsy material was insufficient. CONCLUSION: Pleural biopsy is one of the significant tool in the final diagnosis of exudative pleural effusion. I will be more accurate if microbiological and immunohistochemical markers are added as adjuvant diagnostic tools.

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