Shoaib Ahmed Quershi, Kausar Rehman, Din Muhammad, Muhammad Iqbal Khan, Hafsa Jaffar.
Validity of Mammographm According To Bi-RADS Scoring In Relation with Histopathology among Females Presenting With Clinically Palpable Breast Lump or Nipple Discharge.
Ann Pak Inst Med Sci Jan ;10(3):150-4.

Objective: To determine the validity of mammogram according to BI-RADS scoring in relation with histopathological findings in female presenting with clinically palpable breast lump or nipple discharge. Study Design: Cross sectional study Place Of Study: Department of General Surgery Unit-I Sandeman Provincial Hospital Quetta, during a period of six months i.e. from January 2014 to 31st of July 2014. Material and Methods: Seventy-six females of age above 35 years with clinical or susceptible breast lump or nipple discharger in the surgical OPD were included in the study while pregnant women, previously diagnosed patients or recurrent breast carcinoma patients were excluded from study. The women were examined after having appropriate history of lump or nipple discharge and were advised mammography for detecting lesions. Suspicion of breast cancer on BI-RADS mammogram was considered for categories 1-5 from either site of breast while category-0 was considered negative. Later on biopsy (FNAC/trucut/Excision) of the lesions was done to confirm the findings of mammography according to the newly introduced BI-RADS classification. Result: Out of 76 clinically suspected patients 71 were confirmed on biopsy, out of which 62 suspected cases on BI-RADs mammogram were true positive yielded 81.58% sensitivity of BI-RADS mammogram while 9 cases were false negative. All five negative cases were true negative yielded 100% specificity of BI-RADS mammogram in diagnosis of breast cancer. Out of 62 positive cases on BI-RADS mammogram, all 62 cases were true positive that revealed 100% positive predictive value of BI-RADS Mammogram. Out of 14 cases which were negative for breast cancer diagnosis on BI-RADS mammogram, 5 cases were true negative that reveals 35.71% negative predictive value. Overall accuracy of BI-RADS mammogram in the diagnosis of breast diseases was 88.16%. Conclusion: BI-RADS mammography is sufficiently sensitive and highly specific as an important diagnostic tool for the diagnosis of breast diseases and where there is doubt; diagnosis should be made by mean of triple assessment i-e clinical examination, mammography and histopathological results together.

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