Sajid Mumtaz Qazi, Wajeed Gul.
Trial Without Catheter with Alpha Blockers in Acute Urinary Retention due to Benign Prostatic Hyperplasia.
Ann Pak Inst Med Sci Jan ;12(3):166-70.

Background: Benign Prostatic Enlargement is one of leading cause of Acute Urinary Retention, various modalities are available for treatment of Benign Prostatic Enlargement and Acute Urinary Retention. Objective: This study was conducted to evaluate the clinical efficacy of Uroselective Alpha-1A blocker (Tamsolosin) in the treatment of Acute Urinary Retention due to Benign Prostatic Enlargement. Place and Duration: This randomized controlled trial (RCT) was conducted at the Department of Urology and Renal Transplantation, Pakistan Institute of Medical Sciences, Islamabad between September 23, 2011 and March 23, 2012. Materials and Methods: This Randomized controlled trial included 120 patients over age of 50 years, which were randomly divided in two groups i.e. tamsolosin group and control group of 60 patients each. All the patients were treated with Urethral Catheter and in treatment group, Tamsolosin 0.4 mg once a day for 3 days was administered. The catheter was removed after 3 days of the treatment. Successful Trial without catheter after 3 days of treatment was the main outcome measure. Results: After removal of catheter, overall 44.1% (53/120) of patients voided successfully. The efficacy was significantly better 58.3% (35/60) in tamsulosin group compared to 30% (18/60) in the control group (p-value = 0.003). Conclusion: Treatment with tamsulosin had a greater rate of success in voiding without catheter after an episode of acute urinary retention. Outcome was significantly influenced by age of the patient and volume of urine drained at the time of catheterization.

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