Nadeem Naseem, Riffet Khurshid, Tehmina Qamar, Syed Farmanullah Hussaini, Munir Tahir, Abdul Khaliq Naveed, Malik S A.
Effects of the Aqueous and Alcoholic Extracts of Seeds of Cichorium Intybus Linn (Kasni) In Treatment of Liver Damaged By Carbon Tetrachloride (CCl4).
Ann Pak Inst Med Sci Jan ;7(4):200-3.

Objective: To determine the role of extracts of seeds of Cichorium intybus linn in the treatment of liver already damaged by Carbon tetrachloride (CCl4). Study Design: Quasi Experimental study. Place and Duration: Materials and Methods: Forty rats were subdivided into four sub groups, ten in each group. Group I was kept as standard control. Group II was sham control. Group III and IV were given aqueous and alcoholic extracts respectively one hour after the liver was damaged by CCl4. Curative effects were assessed by measuring Serum levels of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP). Result: Group I was normal control, on normal rat diet. Group II were given CCl4 orally to damage their liver and no treatment was given enzyme levels of ALP, ALT and AST were significantly raised (Po.ooo) compared to Group I animals. Group III animals liver was damaged by CCl4 and after one hour aqueous extract of seeds of Cichorium intybus linn was given in four doses at 12 hourly interval significant improvement was observed as ALP and AST levels were less than Group II animals (P0.000) and for AST (p0.001) although mean values were more close to group II animals than group I animals. Group 1V animals’ liver was damaged by CCl4 and alcoholic extract was given after one hour significant improvement (P0.000) was observed as serum levels of ALP, AST and ALT were less than Group II animals as compared to Group III animals. Conclusion: Alcoholic extract exhibited more significant hepatocurative effect against CCl4 induced hepatic injury.

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