Noor-ul Ain, Nusrat Bano, Anwar Ejaz Beg, Kamran Hameed, Talha Bin Fayyaz, Rafia Sadaf.
Hematological toxicity in rats; therapeutic properties of andrographis paniculata on oxaliplatin induced.
Professional Med J Jan ;24(2):342-6.
Objectives: Oxaliplatin causes hematological toxicities in clinical setting which limits its efficacy. The aim of this study is to investigate the therapeutic effects of Andrographis paniculata against hematological toxicity caused by oxaliplatin. Study design: Experimental animal study. Period: Study takes 8 month from March 2015 to Oct 2015. Setting: Dow university animal house. Method: Wistar albino male rats, divided into 3 equals groups (n=6): Group N* was a control group (0.9% normal saline), Group NP0 was Oxaliplatin treated group and Group NP1 was prophylactically treated with Andrographis paniculata followed by Oxaliplatin in order to assess the protective effects of Andrographis paniculata against the hematologic toxicity caused by Oxaliplatin. Results: Prophylactic treatment with Andrographis paniculata (NP1) significantly increases the levels of platelets and neutrophile count compared with the standard (NP0) (p<0.01) and increases the RBCs count and levels of hemoglobin compared with the standard (NP0). Conclusion: Prophylactic treatment with Andrographis paniculata (NP1) was effective in reducing risk of thrombocytopenia, anemia and neutropenia associated with Oxaliplatin.
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