Zafar Saied Saify, Kiran Rafiq.
Piperidine - An Important Medicinal Moiety: A Review of its Derivatives as Excellent Analgesics.
Ann Jinnah Sindh Med Uni Jan ;1(1):18-21.

Being an alkaloid and a fragment of morphine, piperidine itself and its derivatives are invasive component for the synthesis of many chief and significant pharmaceuticals. Their medicinal use as analgesic is very ancient and is acknowledged to possess the ability for blocking prostaglandins effects through inhibition of downstream signaling pathways. The present review reflects the marvelous role of piperidine derivative in controlling pain and inflammation. This dimensional pharmacological and biological characteristics have drawn the attraction of researchers and for a long period, specially from two decades, it has become an important area of designing new analgesic moieties along with more excellent therapeutic effects for medicinal chemists, as a result of that thousands of synthetic derivatives containing piperidine with potent activities have been developed and hundreds in a way. Key words: Piperidine, alkaloid, analgesic, morphine.

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