Anjum Kanjee, Afshan Sohail, Aisha Sami.
Topical Isotretinoin in the treatment of Acne Vulgaris: A clinical trial.
J Pak Assoc Derma Jan ;9(3):20-3.

This was a clinical and prospective study conducted to determine the efficacy and incidence of side-effects of topical isotretinoin in the treatment of mild to moderate acne. Fifty cases were included in this study. 0.05% isotretinoin gel was applied daily for Six months. There was a significant reduction in the number of comedones (68.73%) and inflammatory lesions (61.88%) proving the efficacy of topical isotretinoin.

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