Muhammad Yousaf, Jasmine Shah, Muhammad Rasul Jan.
Frequency of Thyroid Dysfunctions in General Population of Peshawar City and Its Association with Serum Alanine Transaminase Level.
Isra Med J Jan ;9(2):84-7.

OBJECTIVE: To determine the frequency distribution of thyroid dysfunctions and its association with Alanine Transaminase (ALT) level in the local population of Peshawar city.. STUDY DESIGN: A Cross sectional study st st PLACE AND DURATION OF STUDY: This study was carried out from 01 March 2014 to 31 June 2014 in Khyber Teaching Hospital (KTH), Peshawar and was approved by the ethical committee of KTH (letter no 21876/KTH/ P.S) METHODOLOGY: The study population consisting of 137 individuals was divided into three groups as “H” (Hyperthyroid); “h” (Hypothyroid) and “N” (Normal control) for the study purpose. Serum T and T analysis was done for all the study population by 3 4 competitive and TSH by sandwich ELISA technique. Serum ALT (Alanine Transaminase) was measured according to IFCC standard protocol. RESULTS: The mean value of ALT of “H” (Hyperthyroid) group was higher (67.07± 187.1 IU/L) as compared to “N”) (53.33 ±33.32 IU/L) and “h'' (Hypothyroid) (32.4± 34.93 IU/L) group. Significant positive correlation was found for ALT with age and TSH in the “N” group (p= 0.04) while negative correlation was observed in the “h” group. In “H” group no significant correlation was observed for ALT with other parameters. CONCLUSIONS: The frequency of thyroid dysfunction was found to be higher in female as compared to male population. Derangement of serum ALT level was observed in both hyperthyroid and hypothyroid patients.

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