Farzana Memon, Tanweer Ahmed Shaikh, Jawaid Hussain Memon, Rasheed Ahmed Soomro.
Pancytopenia: A Clinico-Haematologic Analysis of 100 Cases at Tertiary Care Hospital.
Med Forum Jan ;2(8):80-3.

Object: Pancytopenia is a serious haematological problem, which makes the patient prone to anaemic manifestations, infections and bleeding tandency. Underlying it are many diseases, which are diagnosed by bone marrow aspiration & trephine biopsy. This study was done to describe different etiological causes of pancytopenia in adults population of lower Sindh. Study Design: Cross sectional study. Place & duration: The study was carried out in the department of pathology and diagnostic & research laboratory, Liaquat University of Medical & Health Sciences (LUMHS) Hyderabad in collaboration with medical units of LUMHS Jamshoro from January 2009 to June 2010. Materials and Methods: A total of 100 adult patients with Pancytopenia diagnosed on peripheral blood smear examination were admitted in four medical units of LUMHS Jamshoro during study period, were followed by bone marrow examination and trephine biopsy wherever required. Results: Megaloblastic anaemia was diagnosed in 46% cases, followed by aplastic anaemia in 22% and Acute leukaemia in 10% cases and 5% cases each were diagnosed as hyperspleenism and disseminated tuberculosis. Multiple myelomas were diagnosed in 4% cases, Meylodysplastic syndrome in 3% and Non-Hodgkins lymphoma is seen in 3% and Myelo-fibrosis in 2% cases. Conclusion: It is concluded that Megaloblastic anaemia is most common cause of Pancytopenia in our series followed by aplastic anaemia and acute leukaemia.

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