Asnad, Said Muhammad, Ruqia Fida, Muhammad Ishaq, Israr Ahmed Akhund.
Biochemical Evaluation of Amlodipne / Ramipril in Combination with Essential Hypertension.
Med Forum Jan ;2(8):76-9.

Introduction: The reduction of blood pressure lower than 130/85 mmHg provides additional benefits regarding both protection of organs and cardiovascular mortality. Amlodipine is a calcium channel-blocking agent with vasodilator activity and Ramipril is ACE inhibitor. Objective: the objective of this double-blind, comparative study evaluating the biochemical effects of Amlodipine 5mg and Ramipril 1.25mg in combination and as monotherapy in adult patient with essential hypertension. Study Design. Double-blind, comparative study Place and Duration of Study: This study was conducted at the Department of Biochemistry, University of Karachi from December 2010 to September 2011. Materials and Methods: This was multicenter randomized, double-blind, comparative study. Patients were randomized to receive Amlodopine (5mg) once daily, Ramipril (1.25 mg) once daily and combination of amlodipine 5mg with Ramipril 1.25 mg once daily for 8 weeks and at the end of study biochemical evaluation was done Results: In the patients treated with combination of Amlodipine 5mg and Ramipril 1.25mg tablets showed synergetic effect and no significant biochemical effects Conclusion: We can suggest that good tolerability and no biochemical & hematological effects of combination of Amlodipine 5mg and Ramipril 1.25mg to formulate in a single dosage forms (tablet) because it is an excellent option for the treatment of hypertension in a wide range of hypertensive patients, with a high potential to reduce cardiovascular risks.

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