Ahmad D Siddiqui, Zahra S Sheikh, Mahmood A Shah, Waqas I Khan.
Nortriptyline versus Sertraline comparative efficacy and safety in major Depression.
J Pak Assoc Derma Jan ;10(2):55-9.

Background: To provide data on the safety and efficacy of antidepressants in 40 years or older population, an analysis of data collected from elderly out patients diagnosed to have Major Depression and treated with Sertraline and Nortriptyline was performed. Methods: Out patients (N=30) who met DSM-IV criteria for major depression were randomized to 12 weeks of flexible dose treatment with Sertraline (50-150 mg) or Nortriptyline (25-100 rug). Results: Both treatments significantly improved depression. At weeks 10, 12, and endpoint, Sertraline demonstrated a significantly greater reduction in depression seventy compared to Nortriptyline. Sertraline treatment had significantly more positive effect, when compared to Nortriptyline, across almost all associated measures of cognitive function, energy, anxiety and quality of life and was better tolerated than Nortriptyline, with a lower attrition rate/side effect burden. Conclusion: The efficacy advantages of Sertraline appear to be greater in these patients. It was far more superior to Nortriptyline.

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