Ghulam Nabi Khokhar, Muhammad Khalid, Abdul Latif Ansari, Irshad Ali Alvi, Israr Ahmad Akhund.
Efficacy of Piroxicam in Osteoarthritis.
Med Forum Jan ;2(11):91-3.

Objective: To evaluate the therapeutic efficacy of this most important nonsteroidal anti-inflammatory drug by using series of 60 patients with osteoarthritis. Study Design: Cross sectional study. Place and Duration of Study: The prospecting study was undertaken from amongst patients visiting the outpatient orthopedic department of District Head Quarter Hospital Charsadda of Khyber Pakhtunkhwa (KPK) for the period of six months from 1st January 2011 to 30th June 2011. Materials and Methods: This study was conducted on a mixed population of patients presenting with symptomatic osteoarthritis, which is relatively a common disease. Studies have shown that, the age of 40, 0% of all persons developed from mild clinical symptoms to degenerative changes in their weight bearing joints. Results: indicates a significant therapeutic efficacy as compared to placebo, both at the 2nd and 4th week of treatment. table 3 represent the comparison of Piroxicam with placebo in the reduction of mean walking pain (hip) 2nd & 4th week of treatment on the basis of four point scale. Conclusion: The present study revealed sustained and significant improvement in the osteoarthritis of the knee or hip joint with Piroxicam treatment resulting in marked reduction in night-pain mean walking pain, and improved objective assessment in the functions of affected joints as compared to the findings emerging out of the use of the naproxen, aspirin and placebo.

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