Qurrat-ul Aen Inam, Surraiya Shaikh, Darakhshan Jabeen Haleem.
Neurochemical Profile of 1-(3-Chlorophenyl) Piperazine (m-CPP) in Sucrose Rich Diet Treated Rats.
Ann Jinnah Sindh Med Uni Jan ;2(1):8-12.

Objectives: 1-(3-Chlorophenyl)Piperazine (m-CPP), markedly reduces food intakes in rats and has high affinity for serotonin (5-hydroxytryptamine; 5-HT)-2C receptors. In the present study m-CPP is used to assess possible role of serotonin-2C receptors in sucrose rich diet induced hyperphagia. Methodology: The study was conducted on 24 male albino Wistar rats. Sucrose rich diet was prepared by mixing standard rodent diet and sucrose in the ratio of 3:1 (w/w) and rats were fed freely on this diet for five weeks. After five weeks of treatment normal and sucrose rich diet treated animals were injected with m-CPP at a dose of 3mg/ml/kg to monitor the hypophagic effects of drug on 4h food intake and serotonin metabolism in the hypothalamus. Results: Hypophagic effects of m-CPP were comparable in both groups. m-CPP induced increases of serotonin levels were smaller in sucrose rich diet than normal diet treated rats. Conclusion: Role of serotonin and serotonin-2C receptors in sucrose rich diet induced hyperphagia is discussed. Key words: Sucrose rich diet, Hyperphagia, serotonin-2C.

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