Nadia Parveen, Khwaja Zafar Ahmed, Zafar Saeed Saify, Shafaque Mehboob, Sajid Atif Aleem.
Hepatotoxic Effects of Trichodesma Indicum n-hexane Extract in Mice.
Ann Jinnah Sindh Med Uni Jan ;2(2):56-9.

•Objective: The aim of this study was to evaluate the hepatotoxic effects of Trichodesma indicum (whole pant) n-hexane extract in mice. Method: The extract of the plant was given orally to 50 swiss albino mice for 15 consecutive days. At the end of the treatment period, evaluation of hepatotoxic effects was done on the basis of levels of liver enzyme markers such as alkaline phosphatase, alanin amino transferase, aspartase amino transferases and total bilirubin and histopathological examination of liver tissues. Result: The plant extract significantly increased the liver enzymes and histopathological examination showed alteration in liver structure, vacuolation, karyorrhexis, pyknosis, chromatolysis and necrosis. Conclusion: We conclude that the n-hexane extract of Trichodesma indicum can produce hepatotoxic effects; thereby, precautions should be taken during its traditional therapeutic use. Key words: Trichodesma indicum, n-hexane extract, hepatotoxicity.

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