Hina Abrar, Snh Naqvi, Muhammad Rashid Ahmed, Asma Basharat Ali, Nadia Younus, Rehana Perveen, Hina Yasin.
Effect Of Propranolol; Rifampicin Induced Hepatotoxicity In Rabit`s Liver.
Professional Med J Jan ;24(6):893-8.

Tuberculosis is the disease required long term treatment. Rifampicin is the major element of antiTB therapy if resistance is not documented. Potential of antitubercular dugs to produced hepatoxicity is very high and among all antiTB agents rifampicin (RIF) induced hepatoxicity stands on top. Rifampicin is the major element of antiTB therapy if resistance is not documented. But its hepatotoxic effects are the main hurdle to continue with this therapy. In this study RIF were administered to the rabbit alone or in combination of propranolol to evaluate the hepatotoxic effects of RIF and reduction of hepatotoxicity by propranolol. Histological evaluation of liver tissue on higher magnification, its micrometric analysis and SEM (scanning electron microscopy) of liver were used to estimate the effects of this combination. Micrometry revealed that number of viable hepatocytes, their diameter and nuclear diameter were altered. SEM micrograph showed distorted and swollen hepatic cords. All of these changes successfully turned to normal by combined administration of propranolol. Propranolol successfully improves the hepatic architecture proved by both qualitative and quantitative microscopy.

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