Aftab Ahmed Shaikh, Umair Ali Soomro, Shomail Saeed Siddiqui, Kashif Rasheed Shaikh, Mumtaz Ali Qureshi.
Ascorbic Acid; Renoprotective Effects In Gentamicin Induced Renal Injury In Rats.
Professional Med J Jan ;24(10):1495-500.

Objectives: Investigating the Renoprotective effects of Ascorbic acid in gentamicin induced renal injury (GIRI) in male Wistar rats. Study design: Experimental study. Place and Duration: Animal house of Al-Tibri from September 2016 to December 2016. Methodology: 60 male Wistar rats were selected by non-probability purposive sampling, and were divided into three groups; Group A- control, Group B- Gentamicin induced renal injury (GIRI) (70 mg/kg/bwt i.m) daily , and Group C- GIRI + AA (Ascorbic acid - 0.2 mg/kg/ bwt) daily. Cardiac puncture was performed by a Disposable Syringe for blood sampling. Sera were used for biochemical testing. Renal tissue was stained with H & E for histological examination. Statistix 8.1 software (USA) was used for data analysis at P≤ 0.05. Results: Blood urea and serum creatinine were elevated in the group B (GIRI) compared to GIRI+AA and the controls (P=0.0001). Serum superoxide dismutase, glutathione peroxidase, and catalase were low in GIRI compared to GIRI+AA and control groups. Renal tissue in ascorbic acid treated rats showed improved tissue architecture. Conclusion: It is concluded that the Ascorbic acid exerts Renoprotective effects in gentamicin induced renal injury in rat model.

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