Henna N, Rehman A, Nagi A H.
Expression Of Interstitial Cells Of Cajal In Colorectum Of Patients With Hirschsprung`s Disease.
Biomedica Jan ;33(2):124-7.

Background and Objectives: Precise mechanism underlying the development of Hirschsprung’s disease (HD) is unknown. Interstitial cells of Cajal (ICC) acts as pacemaker and their alteration has been proposed to occur in HD. The aim/rationale of the study is to find out whether there is any difference in number of ICCs in HD and non-HD patients, which in turn will support the assessment of level of disturbed ICCs in the proximal normo-ganglionic segment of HD, in order to improve the post-operative management of HD patients. Methods: The study comprised total of 55 clinically suspected cases of Hirschsprung’s disease. Results: Out of 55, 36 were proved to be HD and 19 composed the Non-Hirschsprung’s disease (NHD) group on H & E examination. The number of ICCs/mm2 in outer muscular layer showed significant (p = 0.033) decrease in HD as compared to NHD group whereas no significant decrease was seen in inner muscular layer. There was significant decrease in number of ICCs/mm2 in outer muscular layer of HD as compared to NHD. Conclusion: Expression of Interstitial cells of Cajal in outer muscular layer of colorectum of Hirschsprung’s disease was significantly reduced.

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