Adnan H A, Kambhoh U A, Majeed S, Imran A A.
Frequency Of CNS Lesions In A Tertiary Care Hospital - A 5 Year Study.
Biomedica Jan ;33(1):4-8.

Background and Objectives: Central nervous system (CNS) lesions range from inflammatory to infectious to neoplastic. Histological spectrum of non-neoplastic and neoplastic lesions is broad and it varies among extremes of age groups. With the aim of determining the diversity of CNS lesions, the study was conducted in a tertiary care hospital in Lahore. Material and Methods: A total of 185 CNS lesions were studied in the Department of Pathology, Allama Iqbal Medical College Lahore in collaboration of Neurosurgery Unit, Jinnah Hospital Lahore from January 2010 to December 2014. The diagnosis was made on routinely processed tissue. The H&E stained sections in all cases were reviewed and diagnosis was confirmed applying revised World Health Organization classification, 2007. Results: A total of 185 CNS lesions were analysed. 107 (58%) were males and 78 (42%) were females. Minimum age of case was 8 years and maximum was 75 years. The most common lesions were of neoplastic nature among which glioma was more common (n = 51) 35% followed by Meningioma (23%). Other lesions include fungal infections, pituitary adenoma, schwannoma, neurofibroma, carotid body paraganglioma, craniopharyngioma, arachnoid cyst, medulloblastoma and medulloepithelioma. Conclusion: This study gives spectrum of non-neoplastic and neoplastic CNS lesions. Moreover, this also gives incidence of various CNS malignancies.

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