Ahtesham K, Jaffer R, Imran AA, Salaria SM, Haseeb MT.
Comparison of agnors size and dispersion with ER staining in invasive ductal carcinoma of breast.
Biomedica Jan ;32(3):194-7.

Introduction: Breast cancer is the most common malignancy and a leading cause of death in women throughout the world. It is the most frequently reported malignancy and a major cause of cancer morbidity and mortality in Pakistan as well. Objective: To compare the Argyrophilic nucleolar organizer regions size and dispersion in estrogen receptor positive and ER-ve tumors of invasive ductal carcinoma of breast. Materials and Methods: Fifty cases of invasive ductal carcinoma of breast diagnosed on trucut, core biopsy/incision/excision were collected from Lahore General Hospital, Lahore. The slides prepared were stained with H&E, AgNOR, and ER immunostains. Results: The mean age of the patients was 46.84 years ± 11.8 SD. AgNOR size and dispersion were significantly of higher grade (p = 0.001 and p < 0.05) in ER-ve tumors than ER+ve tumors. Conclusion: It is concluded that AgNOR size and dispersion correlateinversely with ER status in invasive ductal carcinoma of breast and the results are statistically significant.

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