Abdul Rehman, Shehzad F, Aziz S, Ali H, Zameer M.
Significance of C-reactive protein and albumin in chronic kidney disease patients.
Biomedica Jan ;32(3):183-6.

Background and Objectives: Chronic kidney disease (CKD) and renal failure (RF) are recognised as significant problems for almost of the last 2 centuries. It is more common in adults than in children. The objective of this study is to determine nutritional status, extant of inflammation and the correlation of CRP an Albumin in chronic kidney disease children. Methods: In this cross sectional study a total of 78 patients were included out of which 59 (75.6%) were males and 19 (24.4%) were females, with a male to female ratio of 3:1. The average age was 11.8 years with a standard deviation of ± 3.06 years. Results: Serum CRP levels were high in majority of patients with a mean value of about 21.77 mg/L with a standard deviation of ± 16.44. Serum albumin levels in these patients were found below the normal range giving a mean value of 3.06 g/dl with a standard deviation of ± 1.07. Conclusion: In chronic kidney disease CRP and albumin are very closely related to each other, as the level of CRP increased the albumin goes on decreasing due to inflammation and decreased synthesis by liver. Low levels of albumin are a marker of poor nutritional status in these children.

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