Nadim Hayat Mallick, Shabbir H Sheikh, Ashraf Dar, Saqib Shafi Sheikh, Ammar Hameed Khan, Muhammad Azhar.
Ventricular Arrhythmias; Iatrogenic causes recognition, prevention and management.
Ann King Edward Med Uni Jan ;8(3):146-52.
The most dangerous and life threatening side effects are ventricular tachycardia, fibrillation and sudden death, and other relatively less serious effects like hypotension, negative inotropic effect, sinus brady or tachycardia. These drugs produce repolarization abnormalities in the conduction system of heart producing prolongation of QT interval. Most characteristic of drug-induced proarrhythmia is polymorphous ventricular tachycardia called torsade de pointes in which the QRS axis progresses from positive to negative and back in sinusoidal pattern. This is a review article.
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