Munir Ahmad Azhar, Abid Mahmood, Mohammad Usman Ghani.
Association of Helicobacter Pylori antibodies with cases having non Ulcer Dyspepsia diagnosed on Endoscope.
Ann King Edward Med Uni Jan ;8(3):214-5.
To rind out an association between Helicobacter pylori antibodies and non-ulcer dyspepsia diagnosed on endoscopy, a study was conducted at the Department of Medicine, Bahawal Victoria Hospital, Bahawalpur during a period extending from July 2000 to June 2001. A total of 200 patients between the ages of 20-50 years, presenting with more than three years of dyspeptic symptoms were subjected to upper gastrointestinal endoscopy. Serum specimens from all these cases having non-ulcer dyspepsia were also sent to Agha Khan University Hospital Laboratory for the quantitative detection of H. pylori antibodies. Out of the total patients endoscopied (n=200), 116 (58%) had positive findings on endoscopy. Out of these endoscopy positive cases, 71 (61.20%) had gastritis alone, 15 (12.93%) had gastritis, duodenitis and oesophagitis, 9 (7.75%) had gastric ulcers and 21 (18.10%) had lower end oesophagitis alone. These cases with positive findings (other than ulcers) were evaluated for association with H. pylori antibodies. Majority of these patients was female (n=60) while rest were male (n=47). H. pylori antibodies were detected in 78.87% of gastritis cases, 53.33% of gastritis, duodenitis and oesophagitis cases, and 61.90% of lower end oesophagitis. The study shows that majority of the cases had H. pylori related problem and could be put on therapy for H. pylori without doing endoscopy.
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