Ejaz Ahmed, Anjum Khawar.
A Giant Submandibular Gland Carcinoma Ex-Pleomorphic Adenoma.
Pak J Otolaryngol Jan ;30(3):90-2.

Pleomorphic adenoma(PA) is the most common benign tumor of salivary glands. It has malignant potential if recurrent or left untreated. There are three subtypes of malignant PA: carcinoma ex-pleomorphic adenoma, true malignant mixed tumor and metastasizing pleomorphic adenoma. We report a case of large carcinoma ex-pleomorphic adenoma arising from the right submandibular salivary gland in a 70 years old male. The lesion measured~32×38×29 cm (AP×T×CC) and weighed 7.6 kg. This case report emphasizes that if pleomorphic adenoma left untreated, it can transform into carcinoma ex pleomorphic adenoma. To the best of our knowledge this case of carcinoma ex pleomorphic adenoma of submandibular gland is one of the largest ever reported regionally.

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