Farzana Memon, Nasreen Naz, Furqan Ilyas, Javeria Farooq, Babar Mateen, Saeed Qureshi.
Sensitivity of Shearvawe Elastography in Differentiating Benign & Malignant Solid Breast Lesions.
Ann Pak Inst Med Sci Jan ;13(1):52-6.

Objective: To determine the Sensitivity of Shear wave Elastography to differentiate Benign & Malignant solid breast mass lesions in correlation with Histopathology Study Design: Cross sectional, Descriptive Study Material & Methods: This study comprises of 105consecutive patients with palpable solid breast lesions, were subjected to Ultrasound shear wave elastography followed by Trucut biopsy for Histopathology. Two images of each lesion over the central and pericentral, stiff area were taken. minimum, mean & maximum values were calculated. Statistical analysis were carried out by using SPSS 20. ROC curve was developed. Sensitivity, specificity, PPV, NPV and cutoff values for benign and malignant lesion were calculated in relation to histopathology results Results: A total of105 patients with solid breast lump were evaluated in this study. On histopathology out of 47 benign lesions 21 (44.6%) were found malignant while all 58 clinically and radiologically diagnosed cases were malignant on histopathology. Mean age of the patients with benign histopathology was 43.9±9.7 years while the mean age of patients with malignant histopathology was 43.7±9.2 years. The cut off mean elasticity value was 75kpa any lesion with value above 75 will be malignant while below will be benign. The area under ROC curve were 0.966 for mean 0.848 for minimum, & 0.975 for the maximum elasticity with Sensitivity of 95%, for mean,110.5% for maximum and 52%for minimum Specificity of87.2%, 86.17 %, 80.9% with a PPV of 89.15%, 75%, 89.83% and NPV of 89.13%, 87.87%, 95% for mean, minimum and maximum elastic values respectively. Conclusion: SWE give rise to additional valuable quantitative data to gray scale ultrasound examination on solid breast lesions. It may serve as a complementary method for diagnosis of breast lesions. Although long-term clinical studies are required to accurately select lesions requiring biopsy.

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