Ayesha Fahim, Fauzia Farzana, Mudassar Shehbaz, Zainab Javaid, Fahim Haider Jafari.
Histologic Effects of Carbonated Drinks on Regenerating Buccal Mucosa of Albino Rats.
J Rawal Med Coll Jan ;20(4):323-7.

Background: To assess the effect of carbonated-drinks on regenerating buccal mucosa.Methods: A circular wound of3.0mm was created on the buccal mucosa of 24 Wistar rats and they were divided into two groups. Animals in group-1 were fed with chow pellet and water while those in group-2 were fed with a randomly selected carbonated-drink instead of water. Six animals from each group were sacrificed at 3 and 14 days. Wound site was histologically assessed for differences in the regenerating epithelium and submucosa; inflammatory cell count and neovascularization between two groups.Results: There was marked difference in the pattern of regenerating epithelium between the groups. Animals in group-1 showed a normal regeneration of stratified squamous epithelium at day-3 with significant inflammatory reaction in the submucosa. In group-2 however, there was a delay in epithelial regeneration; with only a two-cell thick layer of epithelium covering the underlying tissue and an altered healing phenomenon at the end of the experiment.Conclusion: Consumption of carbonated-drinks can disrupt oral wound healing process. Studies suggest that low pH of drinks could have detrimental effects on the oral microbiota, inhibiting neutrophil recruitment in the wound area; thus delaying epithelial regeneration at day-3 and subsequent wound healing of the buccal mucosa.

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