Nadia Wali, Tariq Butt, Usman Wali, Zakir Hussain.
Fosfomycin Versus Nitrofurantoin Efficacy Against Multi-Drug Resistant Gram Negative Urinary Pathogens.
J Rawal Med Coll Jan ;20(4):265-8.

Background: To compare antimicrobial susceptibility pattern of fosfomycin and nitrofurantoin against multi-drug resistant gram negative uropathogens.Methods: In this descriptive studyidentification of 200 isolates of gram negative bacteriawas doneby using standard microbiological techniques and the antimicrobial susceptibility was carried out by employing Kirby-Bauer disc diffusion technique. The susceptibility pattern of isolates was then recorded in frequency and percentages.Results: Out of total 200 urinary samples, 97 were multi-drug resistant (MDR) and 103 were non multi-drug resistant gram negative bacteria. Both MDR and non MDR Escherichia coli(E. coli) followed by Klebsiellapneumoniae(K. pneumoniae) were more commonly isolated uropathogens. MDR E. coli was moresusceptible to fosfomycin (98%) as compared to nitrofurantoin (81%). Similarly, for MDR K. pneumoniae, same results of better susceptibility of fosfomycin as compared to nitrofurantoin were observed. Maximum resistance was observedin 4 to 5 drugs in MDR E.coli and K. pneumonia andthe most predominant resistant pattern was observed in ampicillin and cephalosporins .Conclusion: Fosfomycin holds much better in vitro efficacy as compared to nitrofurantoinagainst MDR E. coli, K. pneumoniaeand P. stuartii.

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