Akhtar Zarin Khattak, Abid Sohail Taj, Syed Mukhtar Ali Shah, Farooq Khattak.
Clinical and haematological presentations of haemoglobin E disorders from northern Pakistan.
J Med Sci Jan ;21(3):134-6.

Objective: To evaluate clinical and haematological findings in any form of HbE disorder in Pathan families from Northern Pakistan. Material and Methods: It was a hospital based, prospective observational study, carried out in thalassemic patients, at Haematology Department, Kuwait Teaching Hospital and Fatimid Foundation, Peshawar, from July 2010 to December 2011. Results: During the study period, a total of 13 cases of HbE were detected in 3650 registered thalassemics with an incidence of 0.35%. 6/13 (46%) cases of compound heterozygous HbE / beta thalassemia were found, with four of them behaving as beta Thalassemia Major (BTM) and two as beta Thalassemia Intermedia (TI). 7/13 (54%) cases were heterozygous HbE, all asymptomatic. No case of homozygous HbEE was detected. Conclusion: Haemoglobin E disorders are not uncommon in Pathan families from Northern Pakistan and may behave as BTM or TI.

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