Rahila Bano, Adeel Arsalan, Zufi Shad, Iqbal Ahmad.
Levofloxacin: A Broad Spectrum Potent Antibiotic.
Baqai J Health Sci Jan ;14(1):29-37.

Levofloxacin is a third generation fluoroquinolone antibacterial agent with a broad spectrum activity against Gram-positive, Gram-negative bacteria and atypical pathogens. It shows its bacteriocidal activity by inhibiting topoisomerase IV and DNA gyrase. Levofloxacin has shown strong antibacterial action against Staphylococcus species, Streptococcus pyogenes, Streptococcus pneumoniae. Staphylococcus haemolyticus, Enterobacter species, Escherichia coli, Salmonella species Klebsiella species Serratia species, Enterococcus species, Proteus. Species, Pseudomonas aeruginosa, Haemophilus influenzae and Neisseria gonorrhoea. Moreover, levofloxacin has shown antifungal activity against Chlamydia trachomatis. It is also active against penicillin-resistant Streptococcus pneumoniae. It also possesses lethal effect on resistant mycobacteria like Mycobacterium tuberculosis and Mycobacterium leprae causing tuberclosis and even Mycoplasma species of HIV infection. Levofloxacin is indicated in the treatment of urinary tract infection, respiratory tract infection, biliary tract infection and other infection with clinical efficacy of 80-92%.

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