Muhammad Ali Sheraz, Sofia Ahmed, Iqbal Ahmed.
Effects of Borates on the Stability of Chemical and Pharmaceutical Compounds.
Baqai J Health Sci Jan ;11(1):13-6.

Borate ions are found to have an important role in analytical and kinetic studies both for the purpose of maintaining pH and as a catalyst in the chemical degradation of a number of drugs such as atropine, benzylpenicillin, carbenicillin, cefotaxime, cephradine, hydrocortisone, indomethacin, oxytetracycline, phenylbutazone, minocycline, 5¬-flurouracil, methacoline, octastatin etc. They have also been reported to exert a stabilizing effect on certain drugs including chloramphenicol, epinephrine, riboflavin, alpha-methyldopa, ethyl glucuronide, ribose and glucose. Borate buffer is widely used in ophthalmic formulations for the maintenance of pH and adjustment. Boric acid is involved in the catalysis of a number of reactions of biological importance including the L-arabinose isomerase catalyzed isomerization of D-galactose to D-tagatose in the presence of boric acid.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com