Qamar A Siddiqui.
Peptic Ulcer Therapy: Useful Effect of Non Toxic Herbal Preparation.
Baqai J Health Sci Jan ;12(1):29-34.

Peptic ulcer disease (PUD) is a common problem and about 4 million people suffer from this disease per year in the US. The most common causes of PUD are H pylori infection, over use of NSAIDS, stress, alcohol and tobacco consumption. The anti ulcer drugs are unaffordable and have limitations in their use though are effective. Thus a search for herbal preparations is increasing. Azadirachta indica popularly known as neem has been claimed to be of great medicinal importance. The anti ulcer effects of nimbidin a neem compound have been shown to posses anti ulcer and anti secretory activity in experimentally induced acute and chronic duodenal ulcers and in a clinical trial. The anti ulcer effect of aqueous extract of neem leaves were shown on ethanol induced ulcers in rats. Similarly the gastroprotective effect of neem bark extract has been shown to inhibit 94% of gastric secretion. In pyeloric ligation induced gastric ulceration an 85% inhibition was shown. Bark extract was found to be equipotent to ranitidine and more potent to Omeperazole. Bark extract was provided gastroprotection by inhibition of acid secretion by H+-K+-ATPase and prevention of oxidative damage by OH. The bark extract was more effective than nimbidin. Azadirachta indica have been shown to inhibit basal and histamine induced gastric acid secretion. Neem bark extract has also been shown to have anti ulcer activity in a clinical trial. Thus in this study the anti ulcer effect of methanolic neem leaves extract (NLE) and an isolated compound of neem nimolicine (NC) has been studied and shown to have anti ulcer effects. The anti ulcer effect of NLE was found to be better than NC.Peptic ulcer disease (PUD) is a common problem and about 4 million people suffer from this disease per year in the US. The most common causes of PUD are H pylori infection, over use of NSAIDS, stress, alcohol and tobacco consumption. The anti ulcer drugs are unaffordable and have limitations in their use though are effective. Thus a search for herbal preparations is increasing. Azadirachta indica popularly known as neem has been claimed to be of great medicinal importance. The anti ulcer effects of nimbidin a neem compound have been shown to posses anti ulcer and anti secretory activity in experimentally induced acute and chronic duodenal ulcers and in a clinical trial. The anti ulcer effect of aqueous extract of neem leaves were shown on ethanol induced ulcers in rats. Similarly the gastroprotective effect of neem bark extract has been shown to inhibit 94% of gastric secretion. In pyeloric ligation induced gastric ulceration an 85% inhibition was shown. Bark extract was found to be equipotent to ranitidine and more potent to Omeperazole. Bark extract was provided gastroprotection by inhibition of acid secretion by H+-K+-ATPase and prevention of oxidative damage by OH. The bark extract was more effective than nimbidin. Azadirachta indica have been shown to inhibit basal and histamine induced gastric acid secretion. Neem bark extract has also been shown to have anti ulcer activity in a clinical trial. Thus in this study the anti ulcer effect of methanolic neem leaves extract (NLE) and an isolated compound of neem nimolicine (NC) has been studied and shown to have anti ulcer effects. The anti ulcer effect of NLE was found to be better than NC.

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