Junaid Mahmood Alam, Ishrat Sultana, Syed Riaz Mahmood, Sarah Sughra Asghar, Aijaz Ahmad.
Carcinoembryonic Antigen (CEA): Discovery, Functions, Chemistry and Diagnostic Significances.
Baqai J Health Sci Jan ;10(1):3-14.

The CEA molecule is an onco-development human tumor marker, bearing the cluster differentiation designation of CD66e, a subtype of CD66 group of CEA family. It has a molecular weight of 180 kDa. This antigen was demonstrated in primary tumor of the pancreas and liver, followed by the study of its presence in 1st two Trimesters of gestation. Therefore, the component was designated as Carcinoembryonic Antigen of the human digestive system and subsequently abbreviated as CEA. It became one of the significant entities to diagnose and monitor solid tumor and the response to therapy, especially in GIT cancer. Due to an immense importance of CEA in present day diagnostic and health services, this article reviews the important discovery of CEA by Dr. Phil Gold, its biology, function, chemistry and the clinical role of CEA in categories of cancer screening, diagnosis, prognostic indicator and as a monitoring tool for treatment.

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