Abdul Basit Qureshi, Sajid Mukhtar, Ahmad Raza.
Bacteriological Study Of Bile In Patients With Cholelithiasis.
Esculapio J Services Inst Med Sci Jan ;13(1):51-5.

Objective: To determine the aerobic microbial flora in bile of patients having cholelithiasis. Methods: Study included seventy patients of cholelithiasis, out of which 56 (80%) underwent open cholecystectomy, while 14 (20%) were operated by laparoscopic cholecystectomy. Bile for culture was taken per operatively in all patients. Results: Mean age of patients was 44.17±13.20 and majority of patients were in age group 35- 72. Female to male ratio was 3.4:1. Pain in right hypochondrium was major presenting feature in 65 patients (93%). Mean pain duration was 26.21±23.44 months. Bile culture was positive in 25 (36%) patients.13 (62%) culture positive patients were diabetics. Postoperatively 7 patients (10%) developed fever while 4 patients (5.7%) developed wound infection. Conclusion: SThe frequency of positive bile culture in patients of cholelithiasis was 36%, in this series, commnest organisms being E. coli and Klebsiella. Wound infection 5.7% could have been due to endogenous or exogenous contamination. As all patients who developed wound infection were culture positive in this series, peri-operative antibiotic prophylaxis is recommended in patients undergoing biliary surgery.

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