Naqvi S Q, Abbas R, Jamal Q, Mahmood R K.
Immunohistochemical Determination of HER-2/neu Overexpression in Invasive Ductal Carcinoma of Breast with Cervical Nodal Metastasis.
Pak J Otolaryngol Jan ;18(2):29-31.

This study was designed to determine the frequency of HER-2/neu overexpression, in invasive ductal carcinoma of breast and correlate it with various standard prognostic parameters. This study was performed on formalin fixed paraf n embedded blocks of 72 diagnosed cases of invasive ductal carcinoma of breast. The blocks were retrieved and the staining was done to see the HER-2/neu overexpression. Sections containing > 50% of tumour cells showing intense circumferential cell membrane staining scored as positive. The HER-2/neu overexpression was seen in 31% of cases. A significant relationship (P<0.05) was found between HER-2/neu overexpression and lymphnode status and size of the tumour. The overexpressivity of HER-2/neu oncoprotein suggests that Herceptin can be used as therapeutic measure on these cases.

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