Aafrinish Amanat, Tahmina Gul, Rabia Naseer Khan, Usman Nasir, Romaisa Amanat.
Correlation Between Transglutaminase Antibody (TGA) Ratio And Histological Findings Of Villous Atrophy In Celiac Disease By Marsh Grading.
Esculapio J Services Inst Med Sci Jan ;13(1):14-7.

Objective: To assess the correlation between TGA ratio and degree of duodenal damage by using histologic Marsh grading in patients with CD. Methods: This present study was conducted in the Department of Histopathology, Shaikh Zayed hospital, Lahore. After taking informed consent (from the patients and guardians in case of minors), endoscopic biopsy from the distal duodenum was taken routinely. Data was computerized with window SPSS version 22. Pvalue ≤ 0.05 was considered significant. Results: In our study, the mean age of the patients was 32.23±16.37 years and male to female ratio was 1.08:1. The mean TGA ratio of the patients was 16.51±7.37. A strongly positive correlation was found between the Marsh grading of CD and TGAratio of the patients i.e. r=0.872. Statistically, a highly significant difference was found between Marsh grading and TGAratio.i.e. pvalue=0.006 Conclusion: The results of our study concluded that the titer of TGA ratio is strongly correlated with duodenal histologic Marsh grading in patients of CD.

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