Shahid Mahmood, Faiza Bashir, Irfan Khan, Samina Naeem.
Hepatitis C Liver Dysfunction And Relationship With Hemostatic Disorders.
Esculapio J Services Inst Med Sci Jan ;13(2):106-9.

Objectives: HCV liver disease is associated with abnormal liver functions and often results in various haematological disorders. This study was conducted on 100 HCV positive patients in Mayo Hospital, Lahore. Material and Method: The objective of this study was to establish a relationship between severity of liver disease and subsequent haemostatic disorders. The severity of liver disease was assessed by ALT, AST, Albumin, AST/ALT ratio and APRI Score and Hemostatic disorder was evaluated by Platelet Count, PT, APTT and D-Dimers which showed a significant positive correlation between the severity of liver disease and the increasing hemostatic derangements. Results: The results of the study showed that mean age was 41.29 ± 11.15 years with minimum and maximum ages being 21 and 66 respectively. There were 63% male and 37% female pts and male to female ratio was 1.70:1. In this study the mean PLT count was 202.870 x109/L ± 66.779 x109/Lwith minimum count being 35.000 x 109/L. The PLT count was lower than normal in 21% of the pts. The distribution of D. Dimers was < 0.5 in 42%, 0.5 1 in 55% and it was > 1 in 3% of the pts. The mean PT and APTT were 16 seconds ± 1.81 seconds and 37 seconds ± 4.28 seconds respectively. The PT was prolonged in 48% and APTTin 5% of the patients. Conclusion: The severity of liver disease was assessed by ALT, AST, Albumin, AST/ALT Ratio and APRI Score while the Hemostatic abnormality was checked by Platelet count, PT, APTT and D-Dimers. The results of liver function tests and the coagulation profile along with the levels of AST/ALT Ratio and APRI Score in this study have proved that as the liver disease advances, the hemostatic derangement also increases.

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