Nayyara Tahir, Rukhsana Kausar.
Prevention Of Fall In White Blood Cell Count By Carica Papaya Leaf Juice In Carboplatin Induced Leucopenia In Mice.
Esculapio J Services Inst Med Sci Jan ;13(2):69-73.

Objective: To determine the effect of different doses of male and female papaya leaf juice on prevention of carboplatin induced leucopenia in mice. Methods: A total of 55 Swiss albino mice were randomly divided into five groups (C,M10, M5, F10 and F5).Leucopenia was induced in all groups by a single intraperitoneal injection of carboplatin. Male papaya leaf juice was given to prevent leucopenia to groups M10 and M5 and female papaya leaf juice was given to F10 and F5. On days O, 7, 14 and 21 blood samples were collected by cardiac puncture for white blood cell count. Significance of different was calculated by one way ANOVA. Results: After carboplatin injection, white blood cell count decreased. Papaya leaf juice prevented fall in white blood cell count throughout the study period with p-value < 0.001. White blood cell counts were significantly high in all groups as compared to control on day 7 with no significant difference between gender and dose. Conclusion: Papaya leaf juice prevents leucoopenia induced by carboplatin in a dose dependent manner. There is no difference between male and female plants in this respect.

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