Qamar Sardar, Maliha Fansur, Mamoon Qureshi, Zia Sheikh, Tahir Baig, Nadeem Butt, Khalid Rehman, Tahir Abbas, Tanveer Ahmad, Saleem Cheema, Salman Atiq.
Radiological Feature of Hepatic Cirrhosis in Hepatitis “C” in Pakistan; Our experience at Department of Radiology, Services Institute of Medical Sciences.
Esculapio J Services Inst Med Sci Jan ;7(1):30-4.

Objects: To evaluate the accuracy of liver fibrosis stage by utilizing the techniques of advanced ultrasound performance in patients with chronic liver disease with Hepatitis C. Material and Method: This cross-sectional study was prospectively designed by including 101 consecutive patients with a diagnosis of chronic liver disease including liver cirrhosis between January and December 2010. The ultrasound score was determined from both hepatic lobes and the average scoring was calculated for liver edge, liver surface and liver parenchymal texture. A score of 0 was given when no abnormality was observed; score 1 for mild abnormality; score of 2 for moderate abnormality; and a score of 3 for severe abnormality. Scoring was given for a blunted edge and severe irregular surface or a highly coarse texture only when these characteristics were clearly confirmed by the low frequency probe. Results: Out of 101 subjects, 63.4 % were male and 36.6 % were female with age range of.23- 70 years (mean age 50.73 years SD +/- 10). 17.8 % subjects were between age group 20-40 years, 67.3 % between age group 41- 60 years and 14.9 % between 61 years and above. Mean duration of illness was 2.86 years (minimum 1 year and maximum 15 years). Mean liver size was 12.261 with SD + 2.7145. Mean portal vein size was 1.662 SD + 2.3247. Mean spleen size was 71.71 SD + 32.226. 62.4 % had splenomegaly, 66.3 % had ascites, 56.4 % had bruising and bleeding, 62.4% had varices. 20.8 % had sharp edge 48.5 % had mildly blunted edge and 30.7 % had blunt edge, 11.9% had smooth edge. 33.7% had mildly irregular edge, 39.6 % had irregular edge and 14.9 % had highly irregular edge. Regarding liver parenchymal structure 13.9 % had fine , 22.8 % had mildly coarse, 48.5 had coarse and 14.9 % had highly coarse liver parenchymal structure.15.8 % of subjects had mild fibrosis (score 0 -2) , 55.4 % had moderate fibrosis (score 3 - 5) , 28.7 % had severe fibrosis (score 6 -8). Conclusion: US scoring system is clinically useful for differentiating patients with minimal or no fibrosis from those with mild to severe fibrosis. This is also useful for prognostic information and determining the optimal therapeutic options during the follow-up of chronic liver disease.

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