Saeed Akhtar Malik, Irfan Ahmad, Muhammad Arif Nadeem, Moazzam Ali Atif.
Hepatocellular Carcinoma In Cirrhotic Patients: Frequency, Seroprevalence Of Hepatitis B And C And Patient Profile.
Esculapio J Services Inst Med Sci Jan ;7(3):27-9.

Objective: To find out frequency of hepatocellular carcinoma in cirrhotic patients and to determine seroprevalence of hepatitis B and C and profile of these patients. Material and Methods: This study was done in Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from February to August 2009. One hundred cirrhotic patients admitted in medical wards were evaluated for demographic and clinical features, seroprevalence of hepatitis B and C and Child Pugh score and class. Those having focal defect in liver on ultrasound were further investigated for serum alphafetoprotein, CT scan abdomen and fine needle aspiration for histopathological examination. Results: Eighteen patients were found to have HCC with mean age of 53 years, 78% of these patients were male. Eighty three percent were anti-HCV positive 6% were both HBs Ag and anti-HCV positive and 11% were seonegative. Mean Child score of these patients was 9.16. Main presenting symptoms were massive ascites, hematemesis/melena, hepatic encephalopathy and jaundice. Conclusion: HCC is a common complication of hepatitis C associated cirrhosis.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com