Mansoor A Qureshi, Javaid-ur rehman, Tahir Bajwa.
Effect of 0.5% Bupivacaine at the Surgical Bed After Laparoscopic Cholecystectomy.
Esculapio J Services Inst Med Sci Jan ;8(4):172-5.

Objective: To evaluate the effect of 0.5% bupivacaine irrigated at the surgical bed on postoperative pain relief in laparoscopic cholecystectomy patients. Material & Methods: This study included 80 patients undergoing elective laparoscopic cholecystectomy who were prospectively randomized into 2 groups. The placebo group (n=40) received 20cc saline without bupivacaine, instilled into the gallbladder bed. The bupivacaine group (n=40) received 20cc of 0.5% bupivacaine at the same surgical site. Pain was assessed at 0, 6, 12, and 24 hours by using a visual analog scale (VAS). Results: A significant difference (p=0.018) was observed in pain levels between both groups at 6 hours post operatively.The average analgesic requirement was lower in the bupivacaine group, but this did not reach statistical significance. Conclusion: The use of bupivacaine irrigated in the surgical bed was an effective method for reducing pain during the first postoperative hours after laparoscopic cholecystectomy.

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