Jariya Wajahat, Fatahiya Kashif.
Diabetic Neuropathies: as Indicators of Oxiative Stress & their Correlation to Glucose-6-phosphate Dehydrogenase Activities.
Ophthalmol Update Jan ;12(1):62-5.

Objective: Today diabetes is a major cause of mortality and morbidity. Diabetic complications like neuropathies, are manifestations of oxidative stress. Glucose-6-phosphate dehydrogenase (G6PD) actively plays an important role in oxidative stress by providing NADPH, which helps to fight against oxidative stress. Material & Methods: This study was conducted from March 2009 till February 2010. Eighty subjects were selected from the people who came to get their fasting glucose level checked. These were categorized as controls, high risk individuals, diabetics or metabolic syndrome (MS) sufferers on basis of WHO criteria. The subjects were tested for G6PD activities. G6PD activities were correlated to the extent of development of neuropathies according to Michigan Neuropathy Screening Instrument (MNSI). Results: For MNSI scores showed that mean values of Diabetic and MS groups were significantly higher than that of controls. MNSI scores were correlated to G6PD values. The higher MNSI scores tend to correspond with lower values of G6PD. Conclusion: It may imply that low G6PD activities contribute towards development of complications like diabetic neuropathies or possibly G6PD supplements may help diabetics to prevent development of neuropathies. Further studies including NADPH and Glutathione ratio may help confirm exact role of G6PD in preventing diabetic complications.

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