Junaid F Wazir, Imran Ahmed, Inayat U Khan, Janzeb.
Per-operative use & Safety of 0.5% Intracameral Moxifloxacin Ophthalmic solution as a Prophylaxis during Cataract Surgery to prevent early Post-operative Endophthalmitis.
Ophthalmol Update Jan ;12(1):14-7.

Purpose: To evaluate the per-operative use of 0.5% intracameral moxifloxacin ophthalmic solution as a prophylaxis during cataract surgery to prevent early post- operative endophthalmitis and safety. Material and Methods: This prospective study was conducted in the Department of Ophthalmology Khyber Teaching Hospital, Peshawar, from October, 2010 to September 2011 and comprised of 200 patients. The patients were divided into two groups. Group 1 received 0.1 ml of intracameral moxifloxacin 0.5 % ophthalmic solution at the conclusion of the surgery and the patients in the group 2 were not given the intracameral antibiotic. None of the patients was given postoperative sub conjunctival antibiotic and steroid injection. All patients were examined for AC reaction and pachymetry was done preoperatively and postoperatively (first day, first week and fourth week postoperatively). Anterior chamber reaction and pachymetry values between the two groups were compared .Statistical analysis was done by using paired sample t test. P- value of less than 0.05 was taken as significant. Results: There was no statistically significant difference in corneal oedema (measured by pachymetry) between the two groups on the first postoperative day (p=624), and one month postoperatively (p=0.186). Anterior chamber reaction on the 1st postoperative day was not different in both groups (p=0.610). At 4 weeks there was no reaction in any patients and corneal thickness was also restored to preoperative level. Conclusion: Intracameral moxifloxacin 0.5% ophthalmic solution seems to be safe in terms of AC reaction and endothelial toxicity.

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