Akbar Khoja, Murad Khan, Naheed Qadir, Khalid Fahim Yasin, Muhammad Binyameen, Abdul Baseer.
Effect of NIDDM on Serum Levels of Lipids and Testosterone, in the Middle aged Pakistani Men.
Ann King Edward Med Uni Jan ;5(3,4):270-2.

This study was designed to compare serum testosterone levels in Pakistani diabetic and non-diabetic men and to determine the association of alteration in serum testosterone with diabetic dyslipidaemia. 21 known non-insulin diabetes mellitus (NIDDM) men (mean age 35.29 ± 0 .58 years and BMI 24.67± 0.37 kg/(m.m) ) were selected. Eighteen age and BMI-matched healthy males (mean age 35.71 ± 0.46 and BMI 25.16 ± 0.44) were selected for comparison. In NIDDM subjects significantly higher (P<0.001) levels of serum triglyceride, total cholesterol, and low density cholesterol (LDL-c) levels were observed as compared to controls (129.57±1.94, 208.38±2.54, and 132.99±2.41 mg/dl in NIDDM subjects versus 100.5±1.73, 190.17±2.43, and 109.62±2.42 mg/dl in controls, respectively), while significantly reduced serum levels of HDL-c and testosterone were observed in NIDDM patients when compared to controls (49.48±1.14 mg/dl and 14.05 ± 0.99 nmol/1 in NIDDM subjects versus 60.44±1.16 mg/dl and 19.33 ± 0.87 nmol/a in controls, respectively). A significantly positive correlation was observed between serum testosterone levels and HDL-c both in controls (r = 0.4913 with P<0.05) and NIDDM subjects (r = 0.8338 with P<0.001). An inverse correlation was observed between serum testosterone and triglycerides in controls (r = -0.7617 with P<0.001) and NIDDM (r = -0.8575 with P<0.001). The findings of this study suggest that in middle-aged NIDDM men dyslipidaemia (characterized by elevated levels triglycerides, and decreased levels of HDL-c) is associated with decreased levels of serum testosterone levels. In addition the observations of the present study are also suggestive of association of NIDDM with elevated total cholesterol and LDL-c levels.

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