Yousaf Jan, Waqas Khattak, Aurangzeb Khan, Shaukat Hussain, Irfan-ul Islam Nasir.
Incidence of Prostate Cancer following Trans-Urethral Resection of Prostate (TURP) for Clinically Benign Symptomatic Enlarged Prostate with Normal Prostatic Specific Antigen (PSA).
Ophthalmol Update Jan ;12(2):151-5.

Background: Carcinoma of the prostate is one of the common tumours of old age in men . Both BPH and Prostate cancer share some characteristics: increasing incidence in aging male, dependence on androgens for growth and response to androgen deprivation therapy. Objective: To determine the frequency of carcinoma prostate following TURP for clinically benign prostatic hyperplasia patients with normal serum PSA . Material and Methods: This study was conducted at Hayatabad Medical Complex Peshawar from Feb 2009 to Feb 2011. A total of 135 patients were included in the study. Prostatic Specific Antigen (PSA) was measured pre-operatively and all patients underwent transurethral resection of prostate (TURP) and prostatic tissues were sent to histopathology. Results: A total of 135 patients were included in the study from Feb 2009 to Feb 2011. Patient ages ranged from 50 to 80 years with mean age of 65.67±6.25years. Out of all the patients, 14 patients (10.37%) presented with acute urinary retention, 5 patients (3.70%) with haematuria and 116 patients (85.92%) with Lower Urinary Tract Symptoms (LUTS) . Out of all patients, 25 (18.51%) had serum PSA level less than or equal to 2ng/ml, 48 patients (35.55%) had serum PSA between more than 2 to 3ng/ml and 62 patients (45.92%) had serum PSA of more than 3ng/ml. Histopathology results of 4 patients (2.96%) turned out as adenocarcinoma prostate .Out of these 4 patients, one had carcinoma in situ and 3 having definitive well differentiated adenocarcinoma prostate. Three patients(75%) with malignancy were more than 65 years old while one patient(25%) was aged 59 years . Conclusion: The incidence of carcinoma prostate in clinically Benign Prostate Hypertrophy (BPH) patients with normal PSA is low. Low incidence in present study revealed the usefulness of serum PSA screening method. To avoid unusual systemic needle biopsy for diagnostic purpose serum PSA measurement should be done.

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